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CAS No. : | 103733-65-9 | MDL No. : | MFCD00144038 |
Formula : | C10H11NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | BWKMGYQJPOAASG-SECBINFHSA-N |
M.W : | 177.20 | Pubchem ID : | 712398 |
Synonyms : |
D-phenylalanine analogue
|
Chemical Name : | (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.4% | With thionyl chloride; at 0 - 20℃; for 100h; | Compound 5 (4.27 g, 20 mmol) was added to 20 mL of methanol,After cooling to 0 C, 5.2 mL of thionyl chloride was added dropwise and the mixture was stirred at room temperature for 100 hours.Drying under reduced pressure, the residue was washed with ether,After drying, 4.3 g of light yellow solid compound 6 was obtained in a yield of 94.4%. |
With thionyl chloride; at 0℃; for 2h;Inert atmosphere; Reflux; | Thionyl chloride (210 μL, 3.12 mmol) was added dropwise to a solution of compound 10.1 (150 mg, 0.85 mmol) in methanol (5 mL) at 0 C. The reaction mixture was then refluxed for 2 h. The excess SOCl2 and methanol were then concentrated invacuo to get the crude compound 10.2 (132 mg). This compound was directly used in the next step without further purification. |