成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 103-67-3 Chemical Structure| 103-67-3
Chemical Structure| 103-67-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

{[proInfo.proName]}

CAS No.: 103-67-3

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations      Show More

Mokhtarpour, Nazanin ; Sterling, Alyssa ; Garcia, Joshua J. ; Gutierrez-Rivera, Laura ; Senevirathne, Prasadini ; Luisa Kadekaro, Ana , et al.

Abstract: Reactive oxygen species (ROS) are a heterogeneous group of highly reactive ions and mols. derived from mol. oxygen (O2) which can cause DNA damage and lead to skin cancer. NADPH oxidase 1 (Nox1) is a major producer of ROS in the skin upon exposure to UV light. Functionally, Nox1 forms a holoenzyme complex that generates two superoxide mols. and reduces NADPH. The signaling activation occurs when the organizer subunit Noxo1 translocates to the plasma membrane bringing a cytochrome P 450, through interaction with Cyba. We propose to design inhibitors that prevent Cyba-Noxo1 binding as a topical application to reduce UV-generated ROS in human skin cells. Design started from an apocynin backbone structure to generate a small mol. to serve as an anchor point. The initial compound was then modified by addition of a polyethylene glycol linked biotin. Both inhibitors were found to be non-toxic in human keratinocyte cells. Further in vitro experiments using isothermal calorimetric binding quantification showed the modified biotinylated compound bound Noxo1 peptide with a KD of 2 nM. Both using isothermal calorimetric binding and MALDI (TOF) MS showed that binding of a Cyba peptide to Noxo1 was blocked. In vivo experiments were performed using donated skin explants with topical application of the two inhibitors. Experiments show that UV light exposure of with the lead compound was able to reduce the amount of cyclobutene pyrimidine dimers in DNA, a mol. known to lead to carcinogenesis. Further synthesis showed that the polyethylene glycol but not the biotin was essential for inhibition.

Keywords: Reactive oxygen species ; Apocynin ; UV ; Noxo1 ; Cyba ; Cyclobutane pyrimidine dimer ; CPD ; UV protection

Purchased from AmBeed: ; ; ; ; ;

Hegde, Pooja V. ; Aragaw, Wassihun W. ; Cole, Malcolm S. ; Jachak, Gorakhnath ; Ragunathan, Priya ; Sharma, Sachin , et al.

Abstract: Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action has remained enigmatic. PZA is a prodrug converted by pyrazinamidase encoded by pncA within Mtb to the active moiety, pyrazinoic acid (POA) and PZA resistance is caused by loss-of-function mutations to pyrazinamidase. We have recently shown that POA induces targeted protein degradation of the enzyme PanD, a crucial component of the CoA biosynthetic pathway essential in Mtb. Based on the newly identified mechanism of action of POA, along with the crystal structure of PanD bound to POA, we designed several POA analogs using structure for interpretation to improve potency and overcome PZA resistance. We prepared and tested ring and carboxylic acid bioisosteres as well as 3, 5, 6 substitutions on the ring to study the structure activity relationships of the POA scaffold. All the analogs were evaluated for their whole cell antimycobacterial activity, and a few representative mols. were evaluated for their binding affinity, towards PanD, through isothermal titration calorimetry. We report that analogs with ring and carboxylic acid bioisosteres did not significantly enhance the antimicrobial activity, whereas the alkylamino-group substitutions at the 3 and 5 position of POA were found to be up to 5 to 10-fold more potent than POA. Further development and mechanistic anal. of these analogs may lead to a next generation POA analog for treating TB.

Keywords: Tuberculosis ; Pyrazinoic acid ; pyrazinamide

Giri R. Gnawali ; Koichi Okumura ; Karolina Perez ; Rosa Gallagher ; Julia Wulfkuhle ; Emanuel F. Petricoin , et al.

Abstract: Compound VBT-5445 was identified as an inhibitor to block the association of Pim and the protein Enhancer of Decapping 3 (EDC3), a Pim substrate, which normally functions to enhance the decapping of messenger RNA (mRNA). It was also shown to inhibit both the Pim and mTORC protein kinases. The activity of this compound class can be fine-tuned by structural modification. A series of VBT analogs were designed, synthesized, and evaluated. These compounds decrease the growth of multiple cancer types, including pancreas, prostate, breast, lung, and leukemia. Notably, 6-methyl (GRG-1-31, 6d), 4-chloro (GRG-1-34, 6e), 4-Bromo (GRG-1-35, 6f), and phenylthio substituted (GRG-1-104, 6n) derivatives are highly potent at inhibiting tumor growth. The ability of these compounds to block cancer growth in vitro is highly correlated with their activity as mTORC inhibitors. The toxicity of GRG 1–34 is low in mice treated with twice-daily gavage for 30 days and did not induce weight loss. Pharmacokinetics of a single oral dose demonstrated a peak concentration at 0.5?h after gavage. In summary, further development of this compound class has the potential to inhibit important signaling pathways and impact cancer treatment.

Keywords: Quinoline derivatives ; Pim kinase ; Antitumor activity ; mTORC

Nazanin Mokhtarpour ;

Abstract: Reactive oxygen species (ROS) are a heterogeneous group of highly reactive ions and molecules derived from molecular oxygen (O 2), which can cause DNA damage and lead to skin cancer. High levels of ROS can promote cancer development, cancer cell survival, and resistance to chemotherapeutics. NADPH oxidase (NOX) is a significant producer of ROS in the cell. NOX1 generates two superoxide molecules by reducing NADPH. This only occurs when the membrane-bound NOX cytochrome p450 alpha chain (CYBA) binds to the organizer subunit NOXO1 from the cytosolic portions of the holoenzyme on the cell surface. We propose that stopping NOX1 complex subunits from coming together at this CYBA-NOXO1 junction is a potential way to prevent ROS production in human skin cells when exposed to ultraviolet rays. This dissertation investigates potential small-molecule inhibitors of the crucial NOX1 holoenzyme to solve these issues. We designed and synthesized NOX1 specific Inhibitor 1 using a diapocyin backbone structure. Computational docking studies were used to optimize inhibitor design and evaluate the NOXO1 protein subunit specificity. Due to increased binding interaction with NOXO1 protein and to improve solubility of solution preparation for further physical binding studies, we modified Inhibitor 1 and synthesized Inhibitor 2 by adding the NHS-ester Biotin polyethylene glycol chain to the piperidine ring. Both inhibitors were found to be non-toxic in human keratinocyte cells. The Inhibitor 2 reduced the cyclobutene pyrimidine dimer (CPD) DNA mutation in a human skin explant model. Finally, the isothermal calorimetric (ITC) binding assay and MALDI-TOF mass spectrometry were used for physical binding studies to evaluate the critical molecular interaction, leading to the decreased binding affinity of Inhibitor 1, Inhibitor 2, resulting in additional modifications seen in Inhibitor 3 and Inhibitor 4. The results demonstrate that Inhibitor 2 and Inhibitor 3 reduced the binding affinity between NOXO1 protein and CYBA membrane peptide because of a higher binding interaction of the inhibitors with NOXO1 protein, due to the interaction of the polyethylene glycol chain. In the second section of the project, we computationally design and synthesize NOX1-specific inhibitors using the sequence of CYBA peptides as a modeling tool. Through docking studies, we demonstrated inhibitor interference with NOX1 complexes. Several molecules were designed computationally, and three candidate compounds were tested in vitro and demonstrated a reduction of UVR damage in keratinocyte cells. Biophysical studies, like ITC, were performed to identify interactions. Through these studies, an understanding of protein-protein interactions was gained that are essential for discovering and validating inhibitor candidates, along with information for future inhibitor design. To determine the optimum strategy to utilize the biological features of the small molecule NM-166, a structure-activity relationship analysis was performed.

Purchased from AmBeed: ; ; ;

Alternative Products

Product Details of N-Methylbenzylamine

CAS No. :103-67-3
Formula : C8H11N
M.W : 121.18
SMILES Code : CNCC1=CC=CC=C1
MDL No. :MFCD00008289
InChI Key :RIWRFSMVIUAEBX-UHFFFAOYSA-N
Pubchem ID :7669

Safety of N-Methylbenzylamine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H314-H317-H334
Precautionary Statements:P210-P260-P280-P305+P351+P338-P310
Class:8
UN#:2735
Packing Group:Ⅱ

Application In Synthesis of N-Methylbenzylamine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103-67-3 ]

[ 103-67-3 ] Synthesis Path-Downstream   1~30

  • 1
  • [ 127-17-3 ]
  • [ 103-67-3 ]
  • [ 600-21-5 ]
  • 2
  • [ 1194-21-4 ]
  • [ 103-67-3 ]
  • [ 37409-94-2 ]
  • 3
  • [ 103-67-3 ]
  • [ 26638-43-7 ]
  • [ 87223-28-7 ]
  • 4
  • [ 47355-10-2 ]
  • [ 103-67-3 ]
  • [ 154812-36-9 ]
  • 5
  • [ 114873-01-7 ]
  • [ 103-67-3 ]
  • [ 142995-36-6 ]
  • 6
  • [ 114873-00-6 ]
  • [ 103-67-3 ]
  • [ 142995-34-4 ]
  • 7
  • [ 57-55-6 ]
  • [ 103-67-3 ]
  • [ 2568-25-4 ]
  • 8
  • [ 51323-43-4 ]
  • [ 103-67-3 ]
  • N-methyl-3-(benzylaminomethyl)phenylboronic acid [ No CAS ]
  • 10
  • [ 103-67-3 ]
  • [ 16097-62-4 ]
  • 2-(benzyl-methyl-amino)-6-trifluoromethyl-pyrimidin-4-ol [ No CAS ]
  • 11
  • [ 132898-96-5 ]
  • [ 103-67-3 ]
  • [ 869224-04-4 ]
YieldReaction ConditionsOperation in experiment
15% With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 0 - 20℃; for 2.58333h; Step 1: N-Benzyl-N-methyl-2,3-dioxoindoline-5-sulfonamide To a black solution of 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonylchloride (4.00 g, 16.3 mmol) in 1:1 THF:CHCl3 was added, drop-wise via syringe pump, a solution of N-benzylmethylamine (2.73 mL, 21.2 mmol, 1.3 eq) and N,N-diisopropylethylamine (5.68 mL, 32.6 mmol, 2 eq) in CHCl3 (32 mL) over a period of 1.25 hr. with cooling in an ice bath. After stirring for 50 min. the reaction was allowed to warm to room temperature and stirred for 30 minutes. The reaction was concentrated. The crude product was purified on Biotage KP silica gel eluding with 98/2 CHCl2/CH3OH to give the analytically pure sample of the title compound as a bright yellow solid (0.18 g, 15% yield). Anal. Calc'd for C16H14N2O4S: C, 58.17; H, 4.27; N, 8.48; Found: C, 57.88; H, 4.36; N, 8.40; MS: (API-ES-) m/z 329 [M-H]. m.p.: 183-185 C.
  • 12
  • [ 389602-62-4 ]
  • [ 68957-94-8 ]
  • [ 103-67-3 ]
  • [ 389601-29-0 ]
YieldReaction ConditionsOperation in experiment
95% With 4-methyl-morpholine; In dichloromethane; Example 24 N-phenylmethyl-N-methyl-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide Prepared analogously to Example 7 from 3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid and N-methyl-benzylamine in dichloromethane with the addition of propanephosphonic acid cycloanhydride and N-methylmorpholine. Yield:95% of theory Rf value:0.72 (silica gel; dichloromethane/ethanol=9:1)
  • 13
  • [ 703-67-3 ]
  • [ 103-67-3 ]
  • 2-(N-benzylmethylamino)methyl-6-fluoro-3,4-dihydro-2H-naphthalene-1-one hydrochloride [ No CAS ]
  • [ 529-34-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; paraformaldehyde; In ethanol; water; Step D 2-(N-Benzylmethylamino)methyl-6-fluoro-3,4-dihydro-2H-naphthalene-1-one hydrochloride To an ice-cooled solution of N-benzylmethylamine (5.67 cm3) in ethyl alcohol (60 cm3) was added hydrochloric acid (5 M, 10 cm3). <strong>[703-67-3]6-Fluoro-3,4-dihydro-2H-naphthalene-1-one</strong> (6.00 g) and paraformaldehyde (1.32 g) were then added and the resulting mixture was stirred and heated to reflux for 4 h. Upon cooling, the alcohol was removed under reduced pressure and water (100 cm3) was added. The remaining tetralone was extracted into diethyl ether (100 cm3) and the aqueous mixture was then extracted further with dichloromethane (2*100 cm3). The combined extracts were dried (Na2SO4) and concentrated under reduced pressure. Trituration with diethyl ether and filtration provided the title compound (3.18 g) as a white solid.
  • 14
  • [ 137640-84-7 ]
  • [ 103-67-3 ]
  • C21H17F3N2O2 [ No CAS ]
  • 15
  • [ 149057-19-2 ]
  • [ 103-67-3 ]
  • [ 1311150-40-9 ]
  • 16
  • [ 1920-66-7 ]
  • [ 103-67-3 ]
  • [ 1374993-34-6 ]
  • 17
  • [ 1006-68-4 ]
  • [ 103-67-3 ]
  • [ 2043-61-0 ]
  • N-benzyl-1-cyclohexyl-N-methyl-1-(5-phenyloxazol-2-yl)methanamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
30% General procedure: To an oven dried 10 mL screw cap vial equipped with a stir-bar and charged with amine 1a (0.5 mmol) was added aldehyde 2a (84 mg, 1.5 equiv) and toluene (0.2 mL) and the mixture was stirred for 5 min at room temperature. Thereafter, heteroarene 3a (88 mg, 1.2 equiv) and CuCl (10 mg, 20 mol%) were added and the vial was sealed with a Teflon cap. The reaction mixture was irradiated for 50 min at a preselected temperature of 140 oC, with a maximum irradiation power of 200 W. After completion of the reaction, the resulting mixture was diluted with ethyl acetate (50 mL) and washed with water (50 mL) and brine (50 mL). The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude sample was purified by silica gel column chromatography (10-20% ethyl acetate in heptane) to obtain compound 4a (127mg, 78% yield).
  • 18
  • [ 1798-83-0 ]
  • [ 103-67-3 ]
  • [ 1037492-18-4 ]
  • 19
  • [ 1532-71-4 ]
  • [ 103-67-3 ]
  • [ 132997-51-4 ]
  • 21
  • [ 383-62-0 ]
  • [ 103-67-3 ]
  • N-benzyl-2-chloro-2,2-difluoro-N-methylacetamide [ No CAS ]
  • 22
  • [ 407-97-6 ]
  • [ 103-67-3 ]
  • N-benzyl-5-fluoro-N-methylpentan-1-amine [ No CAS ]
  • 23
  • [ 407-97-6 ]
  • [ 103-67-3 ]
  • C13H20N(1+) [ No CAS ]
  • 24
  • [ 694-82-6 ]
  • [ 103-67-3 ]
  • (1S,2R)-N-benzyl-2-fluoro-N-methylcyclohexan-1-amine [ No CAS ]
  • 25
  • [ 3356-89-6 ]
  • [ 103-67-3 ]
  • N-benzyl-N-methyl-3-phenylisoxazol-5-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With potassium carbonate; In N,N-dimethyl-formamide; for 1.5h;Reflux; General procedure: A mixture of <strong>[3356-89-6]5-chloro-3-phenylisoxazole</strong> (2) (5 mmol), amine (10 mmol) and K2CO3 (15 mmol) in DMF (25 mL) was refluxed under stirring for 1.5 h. The reaction mixture was cooled and diluted with cold H2O (40 mL). For 5a and 5b, the resulting precipitate was collected, washed with H2O and recrystallized from hexane-Et2O. For 5c-e, the reaction mixture was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane-EtOAc, 5:1). 5-Aminoisoxazoles 5a and 5b are known compounds and have full characterization data.
  • 26
  • [ 871231-45-7 ]
  • [ 103-67-3 ]
  • [ 6630-33-7 ]
  • 9-(benzyl(methyl)amino)-9H-fluoren-3-ol [ No CAS ]
  • 9-(benzyl(methyl)amino)-9H-fluoren-1-ol [ No CAS ]
  • 27
  • [ 1709-71-3 ]
  • [ 103-67-3 ]
  • C18H25NO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
at 70℃; for 2h;Cooling with ice; (2) Under ice bath conditions, 39 g of N-methylbenzylamine was added dropwise to the reaction system, and after completion of the dropwise addition, the temperature was raised to 70 C, and the reaction was continued for 2 hours; (3) After the reaction is completed, the temperature is lowered to room temperature, and the product is washed 2-3 times with deionized water, then washed 2-3 times with 1 wt% aqueous NaOH solution, finally washed with deionized water until neutral, transferred to a beaker, and added. An appropriate amount of anhydrous sodium sulfate, dried for 24 hours, and filtered to obtain an active amine-containing acrylate photocurable monomer.
  • 28
  • [ 361-72-8 ]
  • [ 103-67-3 ]
  • N1-benzyl-5-fluoro-N1-methyl-2-nitrobenzene-1,3-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
880 mg In ethanol; at 20 - 50℃; for 23h; 5-(1) N1-Benzyl-5-fluoro-N1-methyl-2-nitrobenzene-1,3-diamine A solution of <strong>[361-72-8]3,5-difluoro-2-nitroaniline</strong> (1.0 g) and N-methylbenzylamine (810 muL) in ethanol (20 mL) was stirred for 18 hours at room temperature. After further addition of N-methylbenzylamine (220 muL), the mixture was stirred under heating for an additional 5 hours at 50C. The reaction mixture was concentrated under reduced pressure and thereafter purified by column chromatography (NH silica gel cartridge, hexane/ethyl acetate = 90:10) to obtain the titled compound (880 mg) as a red solid. MS (ESI pos.) m/z : 276 [M+H]+, RT=1.135 min (Analytical Condition 3)
  • 29
  • [ 79477-87-5 ]
  • [ 536-74-3 ]
  • [ 103-67-3 ]
  • N-benzyl-1-(3-fluorophenyl)-N-methyl-3-phenylprop-2-yn-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With Fe3O4(at)CuSiO3; In neat (no solvent); at 100℃; for 16h;Inert atmosphere; General procedure: A dried reaction tube equipped with a stir bar was loaded with α-keto acids (0.5 mmol), amine (0.65 mmol),alkyne (0.8 mmol), Fe3O4CuSiO3 (3 mg) under the atmosphere of Ar2 at a ceiling temperature of 90 C for 16 h. The resulting reaction mixture was loaded on a silica gel column and flashed with 4-10% ethyl acetate inpetroleum ether to afford the desired product.
  • 30
  • [ 146137-78-2 ]
  • [ 103-67-3 ]
  • 2-(benzyl(methyl)amino)-5-(trifluoromethyl)benzaldehyde [ No CAS ]
 

Related Products

Historical Records

Technical Information

Categories