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N-(2-4'-benzyloxyphenoxypropyl)-3,4-dimethylphenylacetamidine naphthalene-2-sulphonate[ No CAS ]
[ 23194-54-9 ]
Yield
Reaction Conditions
Operation in experiment
In ethanol;
EXAMPLE 96 By the methods of the relevant parts of Example I, 4-benzyloxyphenol was converted to 2-4'-benzyloxyphenoxypropionitrile, b.p. 166-172/0.7 mm., m.p. 84-86 (95% ethanol) and thence to 2-4'-benzyloxyphenoxypropylamine, b.p. 158-160/0.12 mm. The reaction between the amine (2.6 g.), 3,4-dimethylphenyl(thioacetamide) (1.8 g.) and methyl p-toluenesulphonate (1.9 g.) was carried out by the method of the second paragraph of Example III. The reaction mixture was treated with an excess of an aqueous solution of sodium naphthalene-2-sulphonate. The crystalline product was recrystallized from a mixture of ethanol and water and from a mixture of ethanol and ether to give N-(2-4'-benzyloxyphenoxypropyl)-3,4-dimethylphenylacetamidine naphthalene-2-sulphonate, m.p. 82-86.
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