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Chemical Structure| 10284-63-6
Chemical Structure| 10284-63-6

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CAS No.: 10284-63-6

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D-pinitol is a natural compound found in Leguminosae and Pinaceae plants, exhibiting hypoglycemic, cardiovascular protective, and anti-inflammatory activities.

Synonyms: 3-O-Methyl-D-chiro-inositol;3-O-methyl-Chiroinositol;Inzitol;D-(+)-Pinitol;Pinitol;Methylinositol

4.5 *For research use only!

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Product Details of [ D-Pinitol ]

CAS No. :10284-63-6
Formula : C7H14O6
M.W : 194.18
Synonyms :
3-O-Methyl-D-chiro-inositol;3-O-methyl-Chiroinositol;Inzitol;D-(+)-Pinitol;Pinitol;Methylinositol
MDL No. :MFCD00216659
InChI Key :DSCFFEYYQKSRSV-FEPQRWDDSA-N
Pubchem ID :164619

Safety of [ D-Pinitol ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Related Pathways of [ D-Pinitol ]

organic-building-blocks

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00470418 Alzheimer Disease ... More >> Dementia Less << Phase 2 Completed - United States, New York ... More >> VA Medical Center, Bronx Bronx, New York, United States, 10468 Less <<
NCT00470418 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.75mL

5.15mL

2.57mL

51.50mL

10.30mL

5.15mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

Reference

[1]Rengarajan T, Nandakumar N, et al. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pac J Cancer Prev. 2014;15(4):1757-62.

[2]Lin TH, Tan TW, et al. D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways. Int J Mol Sci. 2013 May 8;14(5):9790-802.

[3]Gao Y, Zhang M, Wu T, Xu M, Cai H, Zhang Z. Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats. J Agric Food Chem. 2015 Jul 8;63(26):6019-26

[4]Silva Júnior JAD, Silva ACVFD, Figueiredo LS, Araujo TR, Freitas IN, Carneiro EM, Ribeiro ES, Ribeiro RA. D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice. An Acad Bras Cienc. 2020 Nov 20;92(4):e20201382

[5]Moreira LN, Silva JF, Silva GC, Lemos VS, Cortes SF. Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery. Front Pharmacol. 2018 May 22;9:528

[6]Yao X, Shi K, Yang Y, Gu X, Tan W, Wang Q, Gao X, Priya Veeraraghavan V, Mohan SK, Jin S. D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway. Saudi J Biol Sci. 2020 Aug;27(8):2134-2138

[7]Ma J, Feng S, Ai D, Liu Y, Yang X. D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J Environ Pathol Toxicol Oncol. 2019;38(3):285-295

 

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