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3-Hydroxybenzaldehyde is a precursor to phenolic compounds, produced by the dehydrogenation of 3-hydroxybenzyl-alcohol by enzymes such as aldehyde dehydrogenase (ALDH), and it serves as a substrate for aldehyde dehydrogenases (ALDH) in rats and humans. It has vascular protective effects.
Synonyms: M-Hydroxybenzaldehyde; 3-HBA
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CAS No. : | 100-83-4 |
Formula : | C7H6O2 |
M.W : | 122.12 |
SMILES Code : | O=CC1=CC=CC(O)=C1 |
Synonyms : |
M-Hydroxybenzaldehyde; 3-HBA
|
MDL No. : | MFCD00003368 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35.5 g | With bromine In dichloromethane; water at 0℃; Inert atmosphere | Reaction step: 35.4 g of 3-hydroxybenzaldehyde and 212 ml of dichloromethane were added to a clean reaction vessel, and the mixture was replaced with vacuum nitrogen three times, stirred and cooled to below 0 ° C, 35.4 g of liquid bromine was added dropwise, and 250 ml of water was added after completion of the reaction. Adjust the pH to neutral with liquid alkali, filter by cooling, add 354ml of wet product toluene to dissolve, separate the water layer, warm the organic phase to reflux, filter by temperature, and dry to obtain 4-bromo-3-hydroxy-benzaldehyde 35.5. g. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With potassium carbonate; sodium iodide; In ethanol; for 3h;Reflux; | Example 1 . Preparation of 3-Allyloxybenzaldehyde; [0021] In a 1 L round bottomed flask equipped with mechanical stirrer, reflux condenser and thermometer were added 400 ml_ ethanol, 59.63 g of 3- hydroxybenzaldehyde (0.49 moles, 1 eq.), 7.3 g of sodium iodide (48 mmol, 0.1 eq.), 120.98 g of allyl bromide (0.59 moles, 1 .2eq.) and 101 .6 g of potassium carbonate (0.74 moles, 1 .25 eq.). The reaction mixture was heated to reflux and heating continued for three hours. Heating was then discontinued and the reaction was allowed to cool to room temperature. The mixture was then filtered through a Hyflosupercel pad and ethanol was removed by rotary evaporation. The residual oil was then taken up in 500 ml_ of MTBE and the organic phase washed sequentially with 10% aqueous sodium hydroxide, water and brine. After drying over sodium sulfate, filtration and rotary evaporation of solvent 79.7 g of a yellow oil of 3-allyloxybenzaldehyde (quantitative yield) was obtained. |
100% | With potassium carbonate; In ethanol; for 3h;Reflux; | Example 1 . Preparation of 3-Allyloxybenzaldehyde 3; [0016] In a 1 L round bottomed flask equipped with mechanical stirrer, reflux condenser and thermometer was added in sequence 400 mL ethanol, 59.63 g of 3-hydroxybenzaldehyde (0.49 moles, 1 eq.), 7.3 g of sodium iodide (48 mmol, 0.1 eq.), 120.98 g of allyl bromide (0.59 moles, 1 .2eq.) and 101 .6 g of potassium carbonate (0.74 moles, 1 .25 eq.). The reaction mixture was heated to reflux and heating continued for three hours. Heating was then discontinued and the reaction was allowed to cool to room temperature. The mixture was then filtered through a Hyflosupercel pad and ethanol was removed by rotary evaporation. The residual oil was then taken up in 500 mL of MTBE and the organic phase washed sequentially with 10% aqueous sodium hydroxide, water and brine. After drying over sodium sulfate, filtration and rotary evaporation of solvent 79.7 g of a yellow oil of 3-allyloxybenzaldehyde (quantitative yield) was obtained. |
100% | With potassium carbonate; sodium iodide; In ethanol; for 3h;Reflux; | In a 1 L round bottomed flask equipped with mechanical stirrer, reflux condenser and thermometer were added 400 mL ethanol, 59.63 g of 3-hydroxybenzaldehyde (0.49 moles,1 eq.), 7.3 g of sodium iodide (48 mmol, 0.1 eq.), 120.98 g of allyl bromide (0.59 moles,1.2 eq.) and 101.6 g of potassium carbonate (0.74 moles,1.25 eq.). The reaction mixture was heated to reflux and heating continued for three hours. Heating was then discontinued and the reaction was allowed to cool to room temperature. The mixture was then filtered through a Hyflosupercel pad and ethanol was removed by rotary evaporation. The residual oil was then taken up in 500 mL of MTBE and the organic phase washed sequentially with 10% aqueous sodium hydroxide, water and brine. After drying over sodium sulfate, filtration and rotary evaporation of solvent 79.7 g of a yellow oil of 3-allyloxybenzaldehyde (quantitative yield) was obtained. |
98% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere; | General procedure: To a suspension ofphenol (16, 17, 22, and 23) (1 mmol, 1.0 equiv) and K2CO3(3 mmol, 3 equiv) in anhydrous DMF(5 mL) was added allylbromide (1.5 mmol, 1.5 equiv) dropwise under nitrogenatmosphere at room temperature. The mixture was stirred atroom temperature for 1 h. After completion of the reaction,water (10 mL) was added. The mixture was then extractedwith ether (2 × 30 mL), the combined organic layer waswashed with brine (2 × 30 mL), dried over anhydrousNa2SO4, filtered and the filtrate was concentrated in vacuo.The crude residue was purified by column chromatography (EtOAc/hexane = 1/8) to yield the allyl protected aldehyde(11, 18, 7, and 9). |
98% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 1h;Inert atmosphere; | Phenol (16, 17, 22 and 23) (1 mmol, 1.0 eq.) And Allyl bromide (1.5 mmol, 1.5 eq.) Was added dropwise to a suspension of K2CO3 (3 mmol, 3 eq.) In anhydrous DMF (5 mL) under nitrogen atmosphere at room temperature. The mixture was stirred at room temperature for one hour. After completion of the reaction, water (10 ml) was added. The mixture was extracted with ether (2 x 30 mL) and the organic layer was washed with brine (2 x 30 mL), dried over anhydrous Na2SO4, filtered and the filtrate was concentrated in vacuo. The crude compound was purified by column chromatography (EtOAc / hexane = 1/8) to give aldehydes 11, 18, 7 and 9 protected with allyl groups. |
98% | With 18-crown-6 ether; potassium carbonate; potassium iodide; In acetonitrile; at 75℃; for 18h; | To a stirred solution of 3-hydroxybenzaldehyde (8.0 g, 65.6 mmol) in acetonitrile (80 mL) was added allylbromide (11.0 mL, 131 mmol), KI (1.09 g, 6.56 mmol), 18-crown-6 (864 mg, 3.26 mmol) and K2CO3 (26.4 g, 191 mmol) at rt, after which the solution was refluxed at 75 C for 18 h. The K2CO3 was filtered off and the solvent was removed under reduced pressure·H2O (100 mL) was added and the aqueous layer extracted with EtOAc (2 * 100 mL). The organic layer was separated, washed with brine (50 mL), dried (Na2SO4) and the solvent removed under reduced pressure to yield the title compound as an orange oil, which was used without further purification (10.5 g, 64.4 mmol, 98%). Rf = 0.38 (5% EtOAc in hexane). IR: lambdamax = 2861 (w, C-H), 1681 (s, C=O), 1598 (s, C=C), 1483 (m, C=C), 1457 (m, C=C). 1H NMR (400 MHz, CDCl3): deltaH = 9.92 (1H, s, H10), 7.37-7.44 (2H, m, H6 & H7), 7.36 (1H, dd, J = 2.0, 1.0 Hz, H9), 7.15 (1H, dt, J = 7.2, 2.4 Hz, H5), 5.96-6.09 (1H, ddt, J = 17.2, 10.5, 5.2 Hz, H2), 5.40 (1H, dq, J = 17.3, 1.5 Hz, H1t), 5.28 (1H, dq, J = 10.6, 1.4 Hz, H1c), 4.55 (2H, dt, J = 5.3, 1.4 Hz, H3). 13C NMR (101 MHz, CDCl3): deltaC = 192.0 (C10), 159.1 (C4), 137.8 (C8), 132.7 (C2), 130.1 (C6), 123.5 (C7), 122.0 (C5), 118.0 (C1), 113.1 (C9), 68.9 (C3) . HRMS (ESI+): m/z found [M+H]+ 163.0751, C10H11O2 required 163.0754. |
94.8% | With potassium carbonate; In N,N-dimethyl-formamide; at 25 - 45℃; | Meta hydroxy benzaldehyde (500 g) and potassium carbonate (679 g) were added to DMF (1000 ml). Allyl bromide (569.0 g) was gradually added to the reaction mixture, which was stirred at 25-45C. (0113) After completion of the reaction, water was added to the reaction mass followed by extraction with methyl tertiary butyl ether (MTBE). The organic layer was separated, washed with 1% sodium hydroxide solution (49 g NaOH in 490 ml water) to give compound (2). Yield: 630 g (94.8 %) |
92% | With sodium perborate; In water; at 20℃; for 8.5h;Green chemistry; | General procedure: To the 25 mL round bottomed flask containing 5 mL of water, were added beta-Naphthol (1d, 0.50 g, 1 eq.), sodium perborate (3, 0.214 g, 0.4 eq.), and allyl bromide (2, 0.462 g, 1.1 eq.) and reaction mixture was stirred at room temperature as given time. Progress of the reaction was monitored by TLC. After completion of the reaction (6h), the product was extracted with ethyl acetate (3x15 mL) and combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude residue thus obtained was purified by silica gel column chromatography (100-200 mesh) to afford pure compound 4d. Similar procedure was adopted for the compounds 4a-c, and 4e-j. |
89% | With caesium carbonate; In N,N-dimethyl acetamide; ethyl acetate; | EXAMPLE 58A 3-(allyloxy)benzaldehyde 3-Hydroxybenzaldehyde (1.00 g, 8.19 mmol) and allyl bromide (0.780 mL, 9.01 mmol) in N,N-dimethylacetamide (35 mL) was treated with Cs2CO3 (4.01 g, 12.3 mmol) and allowed to stir at room temperature for 12 hours. The reaction mixture was diluted with diethyl ether (150 mL), washed with 1N HCl, saturated NaHCO3, brine, dried (MgSO4), filtered and the filtrate concentrated. The residue was purified by flash chromatography (silica gel, using 7% ethyl acetate/hexanes as eluent) to provide the title compound as a clear oil (1.19 g, 89%). 1H NMR (CDCl3, 300 MHz) delta 4.82 (m, 2H), 5.25-5.5.50 (m, 2H), 6.03 (m, 1H), 7.18-7.52 (m, 4H), 9.95 (s, 1H); MS (DCI+) 163 (M+H)+. |
83% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 3h; | General procedure: To a solution of 3-hydroxybenzaldehyde 1a (81.9 mmol, 10.0 g) and K2CO3 (1.5 g) in DMF (100.0 mL) was added allyl bromide (7.8 mL) and the mixture was stirred for 3 h at rt. The reaction mixture was quenched with water (50 mL) and the organic phase was extracted into Et2O (3×100 mL), dried over Na2SO4 and the solvent removed at reduced pressure to give a yellow liquid 2a (11.0 g, 83%): FTIR (KBr) 3071, 2818, 1697 cm-1; 1H NMR (200 MHz): delta 9.91 (s, 1H), 7.41 (m, 3H), 7.17 (m, 1H), 6.04 (m, 1H), 5.41 (dd, J 16.0, 6.0 Hz, 1H), 5.30 (dd, J 10.0, 6.0 Hz, 1H), 4.58 (d, J 5.6 Hz, 2H); 13C NMR (50 MHz, CDCl3): delta 191.7, 159.1, 137.7, 132.8, 130.1, 123.6, 122.1, 118.0, 113.1, 68.9; MS(EI) m/z: 162 (M+, 100), 147 (47), 121 (94), 65 (81). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In water; N,N-dimethyl-formamide; | (a) 3-Isopropoxybenzaldehyde 50 g of 3-hydroxybenzaldehyde are dissolved, under nitrogen, in 250 ml of DMF. 60 g of K2 CO3 and then 60 ml of 2-iodopropane are added and the reaction mixture is heated for 18 hours at 50 C. and poured into 2.5 liters of water. Extraction is carried out with ethyl ether and the ether phase is washed with a dilute solution of NaOH, dried over MgSO4 and concentrated under vacuum to give 53.5 g of an oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4.61 g (57%) | In dimethyl sulfoxide; | EXAMPLE 64 N-(1-trans-(3-isopropoxyphenyl)cyclopropyl)methyl)-N-hydroxyurea To a solution of 3-hydroxybenzaldehyde (6.00 g, 49.1 mmol) in DMSO (100 mL) was added potassium t-butoxide (6.34 g, 56.5 mmol) and the resulting mixture was stirred for 20 mins. A sample of 2-bromopropane (7.25 g, 59 mmol) was added and the reaction was stirred for 18 hrs. It was then diluted with brine (100 mL) and extracted with ethylacetate (3*125 mL). The organics were combined, dried with MgSO4 and concentrated. The resulting residue was chromatographed (silica gel, ether:hexanes, 10:90) to afford 4.61 g (57%) of 3-isopropoxybenzaldehyde as a colorless oil. The title compound was prepared according to the procedure of Example 10 substituting trans-(2-(3-isopropoxyphenyl)cyclopropyl)-1-N-methoxy-N-methylcarboxyamide for intermediate 6.2. m.p.=146.5-149.0 C.; 1H NMR (300 MHz, DMSO-d6): 0.86 (t, 2H, J=6.5 Hz), 1.24 (d, 6H, J=6 Hz), 1.31 (m, 1H), 1.80 (m, 1H), 3.35 (m, 2H), 4.57 (septet, 1H), 6.28 (bs, 2H), 6.54-6.68 (m, 3H), 7.11 (t, 1H, J=8 Hz), 9.29 (s, 1H); MS (M+H)+=265; Analysis calc'd for C14 H20 N2 O3: C, 63.61, H, 7.61, N, 10.60; Found: C, 63.54, H, 7.64, N, 10.57. |
4.61 g (57%) | In dimethyl sulfoxide; | EXAMPLE 64 N-(1-trans-(3-isopropoxyphenyl)cyclopropyl)methyl)-N-hydroxyurea To a solution of 3-hydroxybenzaldehyde (6.00 g, 49.1 mmol) in DMSO (100 mL) was added potassium t-butoxide (6.34 g, 56.5 mmol) and the resulting mixture was stirred for 20 mins. A sample of 2-bromopropane (7.25 g, 59 mmol) was added and the reaction was stirred for 18 hrs. It was then diluted with brine (100 mL) and extracted with ethylacetate (3*125 mL). The organics were combined, dried with MgSO4 and concentrated. The resulting residue was chromatographed (silica gel, ether:hexanes, 10:90) to afford 4.61 g (57%) of 3-isopropoxybenzaldehyde as a colorless oil. The title compound was prepared according to the procedure of Example 10 substituting trans-(2-(3-isopropoxyphenyl)cyclopropyl)-1-N-methoxy-N-methylcarboxyamide for intermediate 6.2. m.p.=146.5-149.0 C.; 1H NMR (300 MHz, DMSO-d6): 0.86 (t, 2H, J=6.5 Hz), 1.24 (d, 6H, J=6 Hz), 1.31 (m, 1H), 1.80 (m, 1H), 3.35 (m, 2H), 4.57 (septet, 1H), 6.28 (bs, 2H), 6.54-6.68 (m, 3H), 7.11 (t, 1H, J=8 Hz), 9.29 (s, 1H); MS (M+H)+=265; Analysis calc'd for C14 H20 N2 O3: C, 63.61, H, 7.61, N, 10.60; Found: C, 63.54, H, 7.64, N, 10.57. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 213 3-(3-Hydroxy-benzylamino)-4-methoxy-N-phenyl-benzamide The title compound has been made using the procedure of Example 50, but using 3-amino-4-methoxy-N-phenyl benzamide and 3-hydroxybenzaldehyde as starting materials, which are commercially available from Aldrich; m.p. 168-170 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80.9% | In ethanol;Reflux; | General procedure: solutionof acid hydrazide (0.01 mol) and appropriate benzaldehyde/acetophenone (0.01 mol) in ethanol was refluxed for 5-6 h. The precipitated title compounds were then filtered off, washed with water and recrystallized from ethanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation; | General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r. |
In ethanol; at 70 - 80℃; for 3h; | General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With sodium metabisulfite; In ethanol; water; for 24h;Reflux; | General procedure: To a solution of the appropriate 3,4-diaminobenzene derivative (1ad)(2 mmol) in ethanol (15 mL) 2.85 N aqueous solution of sodium metabisulphite (1.6 mL) and the appropriate substituted arylaldehyde(2 mmol) were added. The reaction mixture was heated at reflux for 24 h. The solvent was then evaporated under reduced pressure. The residue was added with HCl 1 N (10 mL), the formed precipitate was filtered off, washed with water (3×10 mL) and purified by crystallization from the adequate solvent to give the title compounds.Following the general procedure benzimidazoles 3 [19], 4 [20], 5 [21],7 [24], 6, 32 and 33 [15] were prepared and their analytical and spectral data are in agreement with those reported in literature. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | for 0.133333h;Microwave irradiation; | General procedure: Second step consists of condensation of <strong>[6761-52-0]3-aminopyrazine-2-carbohydrazide</strong> (0.5 gm, 0.003 mol) with aromatic aldehydes (0.5 gm, 0.008 mol) using microwaveirradiation (8 - 10 min, 350 W). After cooling and filtration,the product was recrystallized using ethanol [6, 9] (Fig. 1). |
Tags: 3-Hydroxybenzaldehyde | Aldehydes | Phenols | Benzene Compounds | Fluorinated Building Blocks | Aryls | Organic Building Blocks | By Structure | 100-83-4
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P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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