久久一区二区精品综合,久久9966精品国产免费,久久中文字幕美谷朱里

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

 
 
Loading Please Wait...
  V2458    
Quizartinib
, 99% (HPLC), powder
 
AC220




IDENTITY
CAS Number:950769-58-1
MDL Number:MFCD18074524
MF:C29H32N6O4S
MW:560.67
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:212-218°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 112 mg/mL
Application(s):Inhibitor of Flt3(ITD) and Flt(wt)

REVIEW

 Quizartinib is an orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FLT3, CSF1R, SCFR, and PDGFRs, resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis.

REFERENCES
[1]Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, Sprankle KG, Patel HK, Levis M, Armstrong RC, James J, Bhagwat SS. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).Blood. (2009) Oct 1;114(14): 2984-92.
[2] Kampa-Schittenhelm KM, Heinrich MC, Akmut F, D?hner H, D?hner K, Schittenhelm MM. Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Mol Cancer. (2013) Mar 7;12: 19.
[3] Ostronoff F, Estey E. The role of quizartinib in the treatment of acute myeloid leukemia.Expert Opin Investig Drugs. (2013) Dec;22(12): 1659-69.
[4] Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.Preparation of imidazolothiazole compounds for treatment of proliferative diseases or autoimmune diseases PCT Int. Appl. (2007), WO 2007109120 A2 20070927.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of November 17, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives >


PubChem
?