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REVIEW Tetracaine also known as amethocaine (trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. It can be applied as a cream or as a patcvh, plaster or peel. In regard to its mode of action, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
REFERENCES
[1]
WIEDLING S; TEGNER C LOCAL ANESTHETICS Progress in medicinal chemistry (1963), 19, 332-98.
[2]
Covino B G Comparative clinical pharmacology of local anesthetic agents Anesthesiology (1971), 35(2), 158-67.
[3]
Webb, Alistair I.; Pablo, Luisito S. Edited by Riviere, Jim Edmond; Papich, Mark G Local Anesthetics Veterinary Pharmacology and Therapeutics (9th Edition) (2009), 381-399.
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