DMSO =45mg/mL, Water <1.2mg/mL, Ethanol <1.2.mg/mL
Application(s):
Inhibitor of PARP1 and PARP2
Form:
Free base
Research Area:
Melanoma, breast carcinoma
REVIEW ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.
REFERENCES
[1]
Ji J, Kinders RJ, Zhang Y, Rubinstein L, Kummar S, Parchment RE, Tomaszewski JE, Doroshow JH.Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells.PLoS One. 2011;6(10):e26152. Epub 2011 Oct 10.
[2]
Kummar S, Ji J, Morgan R, Lenz HJ, Puhalla SL, Belani CP, Gandara DR, Allen D, Kiesel B, Beumer JH, Newman EM, Rubinstein L, Chen A, Zhang Y, Wang L, Kinders RJ, Parchment RE, Tomaszewski JE, Doroshow JH.A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas.Clin Cancer Res. 2012 Mar 15;18(6):1726-34. Epub 2012 Feb 3.
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