REVIEW A triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Fluconazole inhibits the fungal cytochrome P450 enzyme 14a-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14a-methyl sterols.[
REFERENCES
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St Clair K, Maguire JD (2012). Role of fluconazole in a case of rapid onset ritonavir and inhaled fluticasone-associated secondary adrenal insufficiency. Int J STD AIDS. 23(5):371-2. PMID 22648897.
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Pawar B, Joshi M, Srivastava S, Kanyalkar M (2012). In search of a novel antifungal agent: probing molecular interactions of fluconazole and its analogues with model membranes by NMR and DSC techniques. J Pharm Pharmacol. 64(6):802-10. PMID 22571258.
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