REVIEW Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen.
REFERENCES
[1]
Lecomte, J. M. An overview of clinical studies with racecadotril in adults. International Journal of Antimicrobial Agents. (2000) 14(1): 81-87
[2]
Szajewska, H.; Ruszczynski, M.; Chmielewska, A.; Wieczorek, J. Systematic review: racecadotril in the treatment of acute diarrhea in children. Alimentary Pharmacology and Therapeutics. (2007) 26(6): 807-813.
[3]
Eberlin, Marion; Mueck, Tobias; Michel, Martin C. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. Frontiers in Gastrointestinal Pharmacology. (2012) 3(May): 93.
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Roques, Bernard; Schwartz, Jean Charles; Lecomte, Jeanne Marie Amino acid derivatives and their therapeutic use Eur. Pat. Appl. (1981), EP 38758 A1 19811028.
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