REVIEW Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
REFERENCES
[1]
Kaneshiro B, Edelman A, Carlson NE, Nichols M, Jensen J (2012). Unscheduled bleeding with continuous oral contraceptive pills: a comparison of progestin dose. Contraception. 86(1):22-7. PMID 22176792.
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Archer DF, Stanczyk FZ, Rubin A, Foegh M (2012). Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial. Contraception. 85(6):595-601. PMID 22133660.
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Edgren RA, Stanczyk FZ: Nomenclature of the gonane progestins. Contraception. 1999 Dec;60(6):313.
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Sitruk-Ware R: New progestagens for contraceptive use. Hum Reprod Update. 2006 Mar-Apr;12(2):169-78. Epub 2005 Nov 16.
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