REVIEW Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.
REFERENCES
[1]
Lumry W, Prenner B, Corren J, Wheeler W (September 2007). Efficacy and safety of azelastine nasal spray at a dose of 1 spray per nostril twice daily. Annals of Allergy, Asthma & Immunology 99 (3): 267-72. doi:10.1016/S1081-1206(10)60663-1. PMID 17910331.
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Ciprandi G, Ricca V, Passalacqua G, et al. (March 1997). Seasonal rhinitis and azelastine: long- or short-term treatment?. The Journal of Allergy and Clinical Immunology 99 (3): 301-7. doi:10.1016/S0091-6749(97)70046-0. PMID 9058684.
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Horak, Friedrich; Zieglmayer, Ursula Petra (2009). Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Review of Clinical Immunology 5 (6): 659-69. doi:10.1586/eci.09.38. PMID 20477689.
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Greiff L, Andersson M, Svensson C, Persson CG (April 1997). Topical azelastine has a 12-hour duration of action as assessed by histamine challenge-induced exudation of alpha 2-macroglobulin into human nasal airways. Clinical and Experimental Allergy 27 (4): 438-44. doi:10.1111/j.1365-2222.1997.tb00730.x. PMID 9146938.
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