SN-22, (4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, Irinotecan Related Compound E
IDENTITY
CAS Number:
78287-27-1
MDL Number:
MFCD06657922
MF:
C22H20N2O4
MW:
376.41
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
>98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
271-274°C
Optical Rotation:
+40 - +46° (c=0.4, CHCl3:MeOH=8:2)
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
REVIEW 7-Ethylcamptothecin is an advanced intermediate in the preparation of irinotecan, a topoisomerase I inhibitor used as an anticancer drug. It has also been shown to have antitumor activity itself.
Sawada, Seigo; Nokata, Kenichiro; Furuta, Tomio; Yokokura, Teruo; Miyasaki, Tadashi Chemical modification of an antitumor alkaloid camptothecin: synthesis and antitumor activity of 7-C-substituted camptothecins Chemical & Pharmaceutical Bulletin (1991), 39(10), 2574-80.
[3]
Sawada S; Yaegashi T; Furuta T; Yokokura T; Miyasaka T Chemical modification of an antitumor alkaloid, 20(S)-camptothecin: E-lactone ring-modified water-soluble derivatives of 7-ethylcamptothecin Chemical & pharmaceutical bulletin (1993), 41(2), 310-3.
[4]
Lin, Chien-Hsing; Cheng, Yung-Fa; Cheng, Kau-Ming Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin PCT Int. Appl. (2004), WO 2004100897 A2 20041125.
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