2-Amino-3-(ethoxycarbonylamino)-6-(4-fluorobenzylamino)pyridine Maleate Salt
IDENTITY
CAS Number:
75507-68-5
MDL Number:
MFCD00941415
MF:
C19H21FN4O6
MW:
420.39
EINECS:
278-225-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
99% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
180-183°C
Long-Term Storage:
Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Form:
Meleate salt
REVIEW Flupirtine is an aminopyridine that functions as a centrally acting non-opioid analgesic, muscle relaxation and neuroprotective agent, without antipyretic or antiphlogistic properties. In particular it has seen success for the treatment of acute and chronic pain, particularly musculoskeletal pain It is unique as a non-opioid, non-NSAID, non-steroidal analgesic. Flupirtine displays indirect NDMA receptor antagonism via activation of potassium channels and is the first representative of a pharmacological class denoted the ''selective neuronal potassium channel openers''.
REFERENCES
[1]
Kornhuber J, Bleich S, Wiltfang J, Maler M, Parsons CG. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67.
[2]
McMahon FG, Arndt WF Jr, Newton JJ, Montgomery PA, Perhach JL. Clinical experience with flupirtine in the U.S. Postgrad Med J. 1987;63 Suppl 3:81-5.
[3]
Schr?der HC, Müller WE. Neuroprotective effect of flupirtine in prion disease. Drugs Today (Barc). 2002 Jan;38(1):49-58.
[4]
Klawe C, Maschke M. Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Expert Opin Pharmacother. 2009 Jun;10(9):1495-500.
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