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BIOLOGICAL INFO
Solubility:
DMSO: 89mg/mL; H2O: 89mg/mL; EtOH: <1mg/mL
Application(s):
Type II topoisomerase inhibitor
Form:
HCl salt
REVIEW Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
REFERENCES
[1]
Ekins S, Williams AJ, Xu JJ (2010). A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 38(12):2302-8. PMID 20843939.
[2]
Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ (2010). Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 23(7):1215-22. PMID 20553011.
[3]
Fox EJ: Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther. 2006 Apr;28(4):461-74.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Mitoxantrone dihydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
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