REVIEW Sulbactam sodium salt is a water soluble beta-lactamase inhibitor with very weak antibacterial action. This drug is given in combination with beta-lactam antibiotics to prevent destruction of the beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.
REFERENCES
[1]
Barth, Wayne Ernest; Penicillanic acid 1,1-dioxides Ger. Offen. (1978), DE 2824535 A1 19781214.
[2]
Barth, Wayne E., Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors. U.S. (1980), US 4234579 A 19801118.
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Sj?vall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84.
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Foulds G. Pharmacokinetics of sulbactam/ampicillin in humans: a review. Rev Infect Dis. 1986 Nov-Dec;8 Suppl 5:S503-11.
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