REVIEW Isepamicin (also known as isepamycin) is an aminoglycoside antibacterial with good activity against strains producing type I 6''-acetyltransferase, a upregulated enzyme present in resistant strains. The antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Recent work has also indicated that isepamicin might be active in vitro against Gram-negative bacteria with resistance to amikacin and other aminoglycosides.
REFERENCES
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Sanders, Christine C.; Sanders, W. Eugene, Jr.; Goering, Richard V In vitro studies with Sch 21420 and Sch 22591: activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci Antimicrobial Agents and Chemotherapy (1978), 14(2), 178-84.
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Bruss, Jon B.; Kostrub, Corwin F.; Armstrong, Eliana Saxon; Cass, Robert T.; Miller, George H.; Aggen, James Bradley; Goldblum, Adam Aaron; Dozzo, Paola; Linsell, Martin Sheringham Preparation of aminoglycosides as antibacterial agents PCT Int. Appl. (2010), WO 2010132839 A2 20101118.
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