8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate salt
Primaquine diphosphate salt
IDENTITY
CAS Number:
63-45-6
MDL Number:
MFCD00013166
MF:
C15H21N3O.2H3PO4
MW:
455.34
EINECS:
200-560-8
BRN:
3812133
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98%
Physical Form (at 20°C):
Solid
Melting Point:
199-206°C
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:
UN2811
Hazard Class:
6.1; Poison
Packing Group:
III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.
BIOLOGICAL INFO
Solubility:
H2O: 50mg/mL
REVIEW Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA.
REFERENCES
[1]
Mihaly GW, Ward SA, Edwards G, Nicholl DD, Orme ML, Breckenridge AM: Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size. Br J Clin Pharmacol. 1985 Jun;19(6):745-50.
[2]
ALVING AS, ARNOLD J, HOCKWALD RS, CLAYMAN CB, DERN RJ, BEUTLER E, FLANAGAN CL: Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine. J Lab Clin Med. 1955 Aug;46(2):301-6.
[3]
Hill DR, Baird JK, Parise ME, Lewis LS, Ryan ET, Magill AJ: Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I. Am J Trop Med Hyg. 2006 Sep;75(3):402-15.
[4]
Cohen RJ, Sachs JR, Wicker DJ, Conrad ME: Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam. N Engl J Med. 1968 Nov 21;279(21):1127-31. P
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