REVIEW Ubenimex, also known as Bestatin, a dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a competitive for leucine aminopeptidase and aminopeptidase-B protease inhibitor. It exerts a direct stimulating effect on lymphocytes (and monocytes) via its fixation on cell surface leucine-aminopeptidase, and an indirect effect on monocytes (and lymphocytes) via aminopeptidase B inhibition of tuftsin catabolism. Thus, it is an immunomodulating agent. Ubenimex has also been studied for use in the treatment of acute myelocytic leukemia. It is also an inhibitor of leukotriene A4 hydrolase and aminopeptidase N.
REFERENCES
[1]
Schorlemmer HU, Bosslet K, Dickneite G, Lüben G, Sedlacek HH, Studies on the mechanisms of action of the immunomodulator Bestatin in various screening test systems. Behring Inst Mitt. 1984 ;(74):157-73.
[2]
Mathé G. Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system? Cancer Detect Prev Suppl. 1987;1:445-55.
[3]
Ota K. Review of ubenimex (Bestatin): clinical research. Biomed Pharmacother. 1991;45(2-3):55-60.
[4]
Hirayama Y, Sakamaki S, Takayanagi N, Tsuji Y, Sagawa T, Chiba H, Matsunaga T, Niitsu Y. Chemotherapy with ubenimex corresponding to patient age and organ disorder for 18 cases of acute myelogeneous leukemia in elderly patients--effects, complications and long-term survival]. Gan To Kagaku Ryoho. 2003 Aug;30(8):1113-8
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
