REVIEW The mechanism of action for chlorprothixene, like other thioxanthenes and phenothiazines, is not fully understood. The sites of action appear to be the reticular activating system of the midbrain, the limbic system, the hypothalamus, and the globus pallidus and corpus striatum. The mechanism appears to be one or more of a combination of postsynaptic blockade of adrenergic, dopaminergic, or serotonergic receptor sites, metabolic inhibition of oxidative phosphorylation, or decrease in the excitability of neuronal membranes.
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Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, Tikhonov VP (December 2007). Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. J Ethnopharmacol 114 (3): 412-6. doi:10.1016/j.jep.2007.08.021. PMID 17890032.
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