REVIEW Osthol is an O-methylated coumarin, which is an active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Pharmacologically , osthol is a calcium channel blocker. Recent studies indicate that osthole also suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway, which indicates potential as a chemopreventive or chemotherapeutic agent for cancers that overexpress HER2.
REFERENCES
[1]
JAMWAL KS, ANAND KK, CHOPRA IC. Pharmacological properties of a crystalline substance (Osthol) isolated from Prangos pabularia Lindl. Arch Int Pharmacodyn Ther. 1962 Aug 1;138:400-11.
[2]
JAMWAL KS, SETHI OP, ANAND KK, CHOPRA IC. 7-METHOXY-8-ISO-PENTENYL COUMARIN (OSTHOL) -- TOXICITY AND ITS MECHANISM OF RESPIRATORY STIMULANT ACTION. Arch Int Pharmacodyn Ther. 1964 Aug 1;150:425-34.
[3]
Chen ZC, Duan XB, Liu KR. The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson. Yao Xue Xue Bao. 1988 Feb;23(2):96-9.
[4]
Li RZ, He YQ, Chiao M, Xu Y, Zhang QB, Meng JR, Gu Y, Ge LP. Studies of the active constituents of the Chinese drug duhuo Angelica pubescents. Yao Xue Xue Bao. 1989;24(7):546-51.
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