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  X7419    AKSci Reference Standard
ZSTK474, 98% (HPLC)
 
2-(Difluoromethyl)-1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-benzo[d]imidazole
IDENTITY
CAS Number:475110-96-4
MDL Number:MFCD08705334
MF:C19H21F2N7O2
MW:417.41
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO =20mg/mL, Water <1.2mg/mL, Ethanol <1.2mg/mL
Application(s):PI3K inhibitor
Form:Free base
Research Area:Cancer

REVIEW
 ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.

REFERENCES
[1]Kong DX, Yamori T.ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.Acta Pharmacol Sin. 2010 Sep;31(9):1189-97. Epub 2010 Aug 23.
[2] Rewcastle GW, Gamage SA, Flanagan JU, Frederick R, Denny WA, Baguley BC, Kestell P, Singh R, Kendall JD, Marshall ES, Lill CL, Lee WJ, Kolekar S, Buchanan CM, Jamieson SM, Shepherd PR.Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).J Med Chem. 2011 Oct 27;54(20):7105-26. Epub 2011 Sep 27.
[3] Duong HQ, Kim HJ, Kang HJ, Seong YS, Bae I.ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine.Oncol Rep. 2012 Jan;27(1):182-8.
[4] Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T.ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.Eur J Cancer. 2012 Apr;48(6):936-43. Epub 2011 Nov 14.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 22, 2025

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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