REVIEW Isoalantolactone is a sesquiterpene lactone compound isolated from the roots of Inula helenium L. which has been used as a medicinal plant. Studies have demonstrated that isoalantolactone possesses antifungal, anti-bacterial, anti-helminthic and anti-proliferative properties (via induction of apoptosis) in a variety of cells.
REFERENCES
[1]
Wu M, Zhang H, Hu J, Weng Z, Li C, Li H, Zhao Y, Mei X, Ren F, Li L, Isoalantolactone Inhibits UM-SCC-10A Cell Growth via Cell Cycle Arrest and Apoptosis Induction. PLoS One. 2013 Sep 30;8(9):e76000.
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Rasul A, Di J, Millimouno FM, Malhi M, Tsuji I, Ali M, Li J, Li X. Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules. 2013 Aug 5;18(8):9382-96.
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Rasul A, Khan M, Yu B, Ali M, Bo YJ, Yang H, Ma T. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res. 2013 Oct;36(10):1262-1269.
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Li Y, Ni ZY, Zhu MC, Dong M, Wang SM, Shi QW, Zhang ML, Wang YF, Huo CH, Kiyota H, Cong B. Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica. Z Naturforsch C. 2012 Jul-Aug;67(7-8):375-80.
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