REVIEW Telaprevir (VX-950), marketed under Incivek and Incivo brand names), is a drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors, specifically inhibiting the hepatitis C viral enzyme NS3.4A serine protease. Telaprevir is only indicated for use against hepatitis c genotype 1 viral infections.
REFERENCES
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Summa V.VX-950 (Vertex/Mitsubishi). Curr Opin Investig Drugs. 2005 Aug;6(8):831-7.
[2]
Lin C, Kwong AD, Perni RB Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infect Disord Drug Targets. 2006 Mar;6(1):3-16.
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Gentile I, Viola C, Borgia F, Castaldo G, Borgia G. Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection. Curr Med Chem. 2009;16(9):1115-21.
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Gentile I, Carleo MA, Borgia F, Castaldo G, Borgia G. The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus. Expert Opin Investig Drugs. 2010 Jan;19(1):151-9.
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