REVIEW IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC50 values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10uM to 200uM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3delta inhibition also plays a role in autoimmune disease suppression.
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