REVIEW Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the ''''P'''' or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the ''''A'''' or acceptor site to the ''''P'''' or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.
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