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REVIEW Etiracetam is an orally-administered racemic nootropic and antiepilieptic drug of the racetam family. its biologically active enantiomeric form is levetiracetam, the S-enantiomer, which is considerably more active than its R-enantiomer, UCB L-060. Etiracetam is a muscarinic acetylcholine receptor (mAChR) agonist and synaptic vesicle glycoprotein 2A modulator. Use of this compound has been replaced by use of levetiracetam, the S-enantiomer.
REFERENCES
[1]
Strubbe, Joseph H. L.; Linz, Raymond A Pharmaceutical (2-oxopyrrolidine)acetamide derivatives Ger. Offen. (1971), DE 2106418 A 19710819.
[2]
Pharmacologically active N-substituted lactams Belg. (1971), BE 762728 A4 19710810.
[3]
Strubbe, Joseph 2-Pyrrolidone derivatives for the treatment of vascular diseases in humans Ger. Offen. (1978), DE 2746761 A1 19780420.
[4]
Sara S J Memory retrieval deficits: alleviation by etiracetam, a nootropic drug Psychopharmacology (1980), 68(3), 235-41.
[5]
Wolthuis O L Behavioural effects of etiracetam in rats Pharmacology, biochemistry, and behavior (1981), 15(2), 247-55.
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