REVIEW Doramapimod is a highly potent cell-permeable N-pyrazole-N''-naphthly urea inhibitor of p38 MAPK that blocks TNFalpha release in LPS-stimulated THP-1 cells. The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1.
REFERENCES
[1]
Regan, John; Breitfelder, Steffen; Cirillo, Pier; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Klaus, Bernhard; Madwed, Jeffrey; Moriak, Monica; Moss, Neil; et al. Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate. Journal of Medicinal Chemistry. (2002) 45(14): 2994-3008.
[2]
'Schreiber S, Feagan B, D''Haens G, Colombel JF, Geboes K, Yurcov M, Isakov V, Golovenko O, Bernstein CN, Ludwig D, Winter T, Meier U, Yong C, Steffgen J; BIRB 796 Study Group. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn''s disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. (2006) Mar;4(3): 325-34.'
[3]
Ryoo S, Choi J, Kim J, Bae S, Hong J, Jo S, Kim S, Lee Y. BIRB 796 has Distinctive Anti-inflammatory Effects on Different Cell Types. Immune Netw. (2013) Dec;13(6): 283-8.
[4]
Cirillo, Pier F.; Gilmore, Thomas A.; Hickey, Eugene R.; Regan, John R.; Zhang, Lin-Hua Preparation of aromatic heterocyclic ureas as antiinflammatory agents PCT Int. Appl. (2000), WO 2000043384 A1 20000727.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
