REVIEW Thiamphenicol glycinate hydrochloride (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia. Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.
REFERENCES
[1]
Portelli, Mario Preparation of D-(+)-threo- and DL-threo-1-(4-methylsulfonylphenyl)-2-dichloroacetamido-3-aminoacetoxy-1-propanol Annali di Chimica (Rome, Italy) (1964), 54(8-9), 816-20.
[2]
Fontana, Angelo; Portelli, Mario; Schoffone, Ernesto Synthesis of chloramphenicol and thiamphenicol glycinates Gazzetta Chimica Italiana (1965), 95(11), 1385-96.
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