REVIEW Bufexama is a benzeneacetamide used as an anti-inflammatory, analgesic, and antipyretic agent on the skin. It is thought to act by inhibiting the enzyme cyclooxygenase, making it a non-steroidal anti-inflammatory drug. Bufexamac was also identified as a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10), which may contribute to its clinical efficacy.
REFERENCES
[1]
Buu-Hoi, Nguyen P.; Lambelin, Georges; Leproivre, Constant; Gillet, Claude; Gautier, Marcel; Thiriaux, Jacques A new nonsteroidal antiinflammatory agent: p-butoxyphenyl-acetohydroxamic acid Compt. Rend. (1965), 261(11 (Groupe 13)), 2259-63.
[2]
Buu-Hoi, N. P.; Lambelin, Georges; Lepoivre, Constant; Gillet, Claude; Thiriaux, Jacques Synthesis of arylacetohydroxamic acids and their amides Belg. (1965), BE 661226 19650917.
[3]
Pavelka K, Wagenhauser F.Therapeutic efficacy of bufexamac in rheumatoid arthritis: a double-blind comparison with indomethacin. Curr Ther Res Clin Exp. 1970 Feb;12(2):69-72.
[4]
Rose BS, Isdale IC, Conlon PW.Use of bufexamac for rheumatoid arthritis. Curr Ther Res Clin Exp. 1970 Mar;12(3):150-3.
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