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BIOLOGICAL INFO
Solubility:
DMSO, Methanol
Application(s):
Antibiotics
REVIEW Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.
REFERENCES
[1]
Burger, Matthew T.; Bioorganic & Medicinal Chemistry 2006, V14(16), P5592-5604.
[2]
Clay KD et al. (2006). Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Annals of Internal Medicine 144 (6): 415-420. PMID 16481451.
[3]
Scheinfeld N. Telithromycin: A brief review of a new ketolide antibiotic. J Drug Dermat 2004;3:409-13. PMID 15303785.
[4]
D Bertrand, S Bertrand, E Neveu, and P Fernandes (2010). Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors. Antimicrobial Agents and Chemotherapy. 54: 5399-5402.
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