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  J96964    AKSci Bulk Reagent
Moxifloxacin HCl, 95%
 
1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
IDENTITY
CAS Number:186826-86-8
MDL Number:MFCD00949117
MF:C21H25ClFN3O4
MW:437.89
BRN:8377447
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:247-250°C
Boiling Point:636°C
Flash Point:>110°C
Optical Rotation:-125.0 to -138.0° (c=0.5, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):An 8-methoxy-fluoroquinolone antibacterial
Form:HCl salt

REVIEW
 Moxifloxacin Hydrochloride is the hydrochloride salt preparation of Moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of DNA gyrase and topoisomerase IV. The 8-methoxy group of Moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other C-8 substituted quinolones, and Moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- and topoisomerase IV-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphylococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible and penicillin-resistant viridans group streptococci, group A streptococci, M. catarrhalis, and H. influenzae in vitro. IC50 data: Streptokinase A: EC5050 = 171 nM (Streptococcus pyogenes serotype M1); Streptococcus sp. ''group A'': EC5050 = 199 nM; DNA gyrase: IC50 = 300 nM (Escherichia coli K-12); Streptococcus: EC5050 = 358 nM; PhoP regulon: IC50 = 420 nM (Salmonella typhi).

REFERENCES
[1]Souli, M., et al. 1998. Int. J. Antimicrob. Agents. 10: 23-30. PMID: 9624540.
[2] Ballow, C., et al. 1999. Clin Ther. 21: 513-522. PMID: 10321420.
[3] Dalhoff, A., 2001. Clin. Infect. Dis. 32: S16-S22. PMID: 11249824.
[4] Dalhoff, A., et al. 2001. Clin. Infect. Dis. 32: S22-S29. PMID: 11249825.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
O381Moxifloxacin HCl
E111Moxifloxacin

Current as of November 15, 2024


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All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


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