REVIEW PD98059 is inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). PD98059 acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 µM). PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction.
REFERENCES
[1]
Tsai CH, Lee SS, Huang FM, Chang YC.Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline.Head Neck. 2012 Sep 10.
[2]
Tang Y, Sun S, Jiang Y, Zheng C, Liu F.Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation.J Exp Clin Cancer Res. 2012 Sep 11;31(1):73.
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