REVIEW GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM respectively. GSK J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800 nM respectively. It shows no activity against other histone demethylases (IC50 >20 uM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 uM.
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