Novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.9
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REVIEW Blonanserin, is a novel atypical antipsychotic agent, marketed in Japan and Korea, with dopamine D(2), D(3)/serotonin 5-HT(2A) antagonistic properties used for the short and long term treatment of schizophrenia. Blonanserin has low affinity for 5-HT2C, adrenergic alfa1, histamine H1, and muscarinic M1 receptors, but displays relatively high affinity for 5-HT6 receptors. These receptor binding profiles may minimize its potential to induce certain adverse effects such as orthostatic hypotension, oversedation, weight gain, metabolic abnormalities, and peripheral anticholinergic side effects.
REFERENCES
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T Tenjin, S Miyamoto. Blonanserin in the treatment of schizophrenia. Nihon Rinsho. 2013 Apr;71(4):660.
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T Kishi, Y Matsuda, H Nakamura, N Iwat. Blonanserin for schizophrenia: systematic review and meta-analysis of double-blind, randomized, controlled trials. J Psychiatr Res. 2013;47(2):149-54.
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Kato K, Yamada K, Maehara M, Akama F, Kimoto K, Saito M, Yano H, Ichimura A, Matsumoto H; Blonanserin in the treatment of delirium. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(1):156-62.
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