REVIEW Buformin delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose by the liver. Buformin and the other biguanides are not hypoglycemic, but rather antihyperglycemic agents. They do not produce hypoglycemia; instead, they reduce basal and postprandial hyperglycemia in diabetics.[
REFERENCES
[1]
Verdonck LF, Sangster B, van Heijst AN, de Groot G, Maes RA: Buformin concentrations in a case of fatal lactic acidosis. Diabetologia. 1981;20(1):45-6.
[2]
Deppermann D, Heidland A, Ritz E, Horl W: [Lactic acidosis-a possible complication in buformin-treated diabetics (author's transl)] Klin Wochenschr. 1978 Sep 1;56(17):843-53.
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