Calcium Channel Blocker; Bone Resorption inhibitor
Form:
Sodium salt
REVIEW Risedronate sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. Its mode of action on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. It also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates such as risedronate appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover.
REFERENCES
[1]
Turchetta, Stefano; Massardo, Pietro; Ciambecchini, Umberto Preparation of amorphous 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid monosodium salt (sodium risedronate) Eur. Pat. Appl. (2005), EP 1571152 A1 20050907.
[2]
Richter, Jindrich; Jirman, Josef Preparation of stable crystalline form of monosodium risedronate hydrate PCT Int. Appl. (2005), WO 2005075487 A1 20050818.
[3]
Adiyaman, Mustafa; Keskin, Huelya; Karliga, Bekir Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1-biphosphonic acid and hydrated forms thereof PCT Int. Appl. (2007), WO 2007068678 A1 20070621.
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