REVIEW Adapalene selectively binds to the nuclear retinoic acid receptor (RAR) subtypes RARβ and RARγ. This selective binding affinity may play a role in adapalene's greater inhibition of keratinocyte differentiation than tretinoin, which was demonstrated in a study using keratinocyte transglutaminase expression as a marker. This inhibition of keratinocyte differentiation and proliferation is responsible for adapalene's comedolytic effect. It has both exfoliating and anti-inflammatory effects.
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Herndon JH Jr, Stephens TJ, Trookman NS, Rizer RL, Preston N, Caveney S, Gottschalk RW (2012). A comparison of the tolerability of adapalene 0.1% cream and adapalene 0.1% lotion in healthy individuals. Skinmed. 10(3):136-42. PMID 22779096.
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