Product Details
| Product Name:
ZM323881 |
CAS No.:
193001-14-8 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | ZM323881 |
| Description | ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC50 of less than 2 nM. |
| In vitro | ZM323881, an anilinoquinazoline compound, functions as a potent inhibitor of VEGFR2 (KDR) tyrosine kinase, displaying exceptional selectivity by significantly limiting its activity compared to that of other receptor tyrosine kinases like PDGFRβ, FGFR1, EGFR, and erbB2 (IC 50 >50 μM). It effectively suppresses VEGF-A-driven endothelial cell proliferation (IC 50 =8 nM) and VEGFR2 tyrosine phosphorylation [1]. Notably, ZM323881 specifically targets VEGFR-2 inhibition without affecting VEGFR-1, EGFR, PDGFR, or HGF receptor activation. Additionally, in HAECs, it completely blocks VEGF-induced ERK phosphorylation at a concentration of 1 μM [2], showcasing its potential therapeutic utility in conditions characterized by abnormal angiogenesis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | ZM323881 | ZM-323881 | ZM 323881 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$66.00/5mg |
VIP5Y
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TargetMol Chemicals Inc.
|
2024-11-19 |
United States