ZLN 024 hydrochloride NEW
| Price | $40 | $73 | $152 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: ZLN 024 hydrochloride | CAS No.: 1883548-91-1 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | ZLN 024 hydrochloride |
| 描述 | ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). |
| 體外活性 | ZLN 024 hydrochloride increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 μM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM. ZLN 024 hydrochloride also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 μM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 μM. ZLN 024 hydrochloride directly activates recombinant AMPK α1β1γ1 and its homolog α2β1γ1 in a concentration-dependent manner[1]. |
| 體內(nèi)活性 | In C57BKS db/db mice, ZLN 024 hydrochloride(15 mg/kg/day; oral) improves glucose tolerance after 4 weeks of treatment. ZLN 024 hydrochloride reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content a |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (124.42 mM), Sonication is recommended. H2O : < 0.1 mg/mL (insoluble) |
| 關(guān)鍵字 | Inhibitor | AMP-activated protein kinase | ZLN-024 | ZLN 024 hydrochloride | inhibit | ZLN 024 Hydrochloride | ZLN-024 Hydrochloride | ZLN024 | ZLN 024 | ZLN024 Hydrochloride | AMPK |
| 相關(guān)產(chǎn)品 | Phenformin hydrochloride | AICAR | Doxorubicin hydrochloride | Adenosine monophosphate | Metformin | Methyl cinnamate | A-769662 | Metformin hydrochloride | Chitosan oligosaccharide | Buformin hydrochloride | HTH-01-015 | AMPK activator 4 |
| 相關(guān)庫 | 抗肺癌化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抗肥胖化合物庫 | 抗乳腺癌化合物庫 | 抗氧化化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | AMPK靶向分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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