Product Details
| Product Name:
zerumbone |
CAS No.:
471-05-6 |
| Purity:
99.75% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | zerumbone |
| 描述 | Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects. |
| 動(dòng)物實(shí)驗(yàn) | Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. |
| 體內(nèi)活性 | Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (229.01 mM), Sonication is recommended.
|
| 關(guān)鍵字 | HSV | Herpes simplex virus | anti-proliferative | sesquiterpene | Epstein-Barr | virus | inhibit | Inhibitor | zerumbone | Monocyclic | anti-cancer | anti-inflammatory | antioxidant |
| 相關(guān)產(chǎn)品 | Butylated hydroxytoluene | Propyl gallate | L-Tartaric acid | Neohesperidin | Sulbutiamine | Adenosine 5'-monophosphate monohydrate | Oxyresveratrol | m-Coumaric acid | Idoxuridine | L-Cystine | Acyclovir | Trolox |
| 相關(guān)庫(kù) | 中藥單體化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥抗炎分子庫(kù) | 天然產(chǎn)物庫(kù) | 抗病毒庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗感染天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$0.00/1kg |
VIP3Y
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Changsha Staherb Natural Ingredients Co., Ltd.
|
2022-09-19 |
United States