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Postion:Product Catalog >Zatebradine hydrochloride
Zatebradine hydrochloride
  • Zatebradine hydrochloride

Zatebradine hydrochloride NEW

Price $45 $71 $157
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-16

Product Details

Product Name: Zatebradine hydrochloride CAS No.: 91940-87-3
Purity: 97% Supply Ability: 10g
Release date: 2024/11/16

Product Introduction

Bioactivity

名稱Zatebradine hydrochloride
描述Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 μM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM, and 1.88 μM, respectively.
體外活性Zatebradine demonstrates a use-dependent inhibitory effect on the cardiac pacemaker current in rabbit sino-atrial node cells, with an observed Kd value of 480 nM.[2]
體內(nèi)活性Zatebradine hydrochloride (0-20 mg/kg; i.p.; for 30 minutes; male C57/Bl6-mice) decreases the heart rate dose-dependently from 600 to 200 bpm (ED50: 1.8 mg/kg).[1]
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 90.0 mg/mL (182.5 mM), Sonication is recommended.
H2O : 90.0 mg/mL (182.5 mM), Sonication is recommended.
關(guān)鍵字Zatebradine Hydrochloride
相關(guān)產(chǎn)品Alinidine | Cilobradine hydrochloride | ZD7288
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | 離子通道庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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