YK-4-279 NEW
| Price | $54 | $79 | $148 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: YK-4-279 | CAS No.: 1037184-44-3 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | YK-4-279 |
| 描述 | YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1. |
| 激酶實(shí)驗(yàn) | Cytosolic phosphorylation of Akt: Hela cells are serum starved for 1 hr and treated with IGF (100ng/mL) or SC79 (4 μg/mL) for 30 minutes. Cells are lysed in Lysis buffer containing 250 mM Sucrose, 20 mM HEPES, 10 mM KCl, 1.5 mM MgCl2, 1 mM EDTA, 1 mM EGTA supplemented with protease inhibitors. Cells are passed through 25 g needle several times and kept on ice for 20 minutes. Total cell lysate is taken at this point. Cell lysates are centrifuged at 100,000 g for 30 minutes. Supernatant is collected as the cytosolic fraction. Pellet is washed with lysis buffer and represents the membrane fraction. Total cell lysate, cytosolic and membrane fractions are resolved by SDS-PAGE and analyzed for phospho-Akt (S473), Total Akt, Tubulin (cytosolic marker) and Orai1 (membrane marker) by western blotting. |
| 體外活性 | In the fusion-positive LNCaP-luc-M mouse tumor model, YK-4-279 effectively inhibits tumor cell proliferation and migration. In the in vivo Ewing's Sarcoma Family of Tumors (ESFT) xenografts, YK-4-279 (1.5 mg/kg i.p.) successfully suppresses growth. |
| 體內(nèi)活性 | In TC32 cells containing EWS-FLI1, YK-4-279 inhibits cell growth by blocking the interaction between EWS-FLI1 and RHA, thereby reducing the level of cyclin D. In ESFT cells, YK-4-279 can suppress cellular proliferation and induce apoptosis. Additionally, in prostate cancer cells positive for fusion, YK-4-279 inhibits the biological activity of ERG and ETV1, leading to decreased cell migration. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 48 mg/mL (131.1 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 68 mg/mL (185.7 mM) |
| 關(guān)鍵字 | chiral | YK 4 279 | anti-proliferation | Inhibitor | YK4279 | Apoptosis | inhibit | breast | pancreatic | enantiomer | prostate | mice | DNA/RNA Synthesis | YK-4-279 | ESFT |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Guanidine hydrochloride | Metronidazole | Sorafenib | Tributyrin | Thymidine |
| 相關(guān)庫(kù) | 細(xì)胞凋亡化合物庫(kù) | DNA 損傷和修復(fù)分子庫(kù) | 經(jīng)典已知活性庫(kù) | 毒性化合物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 細(xì)胞周期化合物庫(kù) | 抗癌化合物庫(kù) | 轉(zhuǎn)錄因子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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