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Postion:Product Catalog >Xentuzumab
Xentuzumab
  • Xentuzumab

Xentuzumab NEW

Price $347 $886 $1450
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Xentuzumab CAS No.: 1417158-65-6
Purity: > 95% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameXentuzumab
DescriptionXentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activation for the study of solid tumours.
In vitroAfter 5 or 10 days of incubation, single-agent Xentuzumab(XENT)or ENZA reduced the viability of VCaP, DuCaP, and MDA PCa 2b cells in a dose-dependent manner. Combination therapy further decreased cell viability compared to monotherapy; likewise, treatment with XENT+ENZA resulted in a significant reduction in the expression of cell cycle genes, ubiquitin-conjugating enzyme E2 C (UBE2C), cyclin-dependent kinase 1 (CDK1), and cell division cycle protein 20 (CDC20) compared to single-agent treatment.[1].
In vivoMonotherapy with ENZA did not inhibit tumor growth. However, the addition of Xentuzumab(XENT)rendered the tumors sensitive to ENZA again, leading to a significant reduction in tumor volume[1].
Storagestore at low temperature | store at -80°C | Shipping with blue ice.
Inhibitors RelatedEthyl gallate | Oridonin | Capivasertib | Indirubin Derivative E804 | SKLB-163 | Scutellarin | Methyl-Hesperidin | Artemisinin | Ceritinib | Honokiol | 2,3-Butanediol | AKT Kinase Inhibitor

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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