Product Details
Product Name:
VU0134992 |
CAS No.:
755002-90-5 |
Purity:
99.86% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | VU0134992 |
Description | VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM |
In vitro | VU0134992 inhibits Kir4.1 with an IC50 value of 0.97 μM and is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50 = 9 μM) at -120 mV.?In thallium (Tl+) flux assays, VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2;?is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1;?and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2. |
In vivo | VU0134992 displayed a large free unbound fraction (fu) in rat plasma (fu = 0.213).?Consistent with the known role of Kir4.1 in renal function, oral dosing of VU0134992 led to a dose-dependent diuresis, natriuresis, and kaliuresis in rats. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 60 mg/ml (145.85 mM)
|
Keywords | whole-cell | VU-0134992 | VU0134992 | selective | Potassium Channel | patch-clamp | oral | natriuresis | Kir4.1 | KcsA | kaliuresis | Inhibitor | inhibit | hypertension | electrophysiology | diuresis |
Inhibitors Related | Minoxidil sulfate | Quinine sulfate dihydrate | Hydrochlorothiazide | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Ursodeoxycholic acid | Cloperastine hydrochloride | Minoxidil | Indapamide |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:536-13-0
$108.00 / 1mg
-
CAS:1052515-91-9
$34.00 / 2mg
-
CAS:2227149-22-4
$117.00 / 1mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$34.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |