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Postion:Product Catalog >VU0134992
VU0134992
  • VU0134992

VU0134992 NEW

Price $68 $141 $212
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: VU0134992 CAS No.: 755002-90-5
Purity: 99.86% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameVU0134992
DescriptionVU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM
In vitroVU0134992 inhibits Kir4.1 with an IC50 value of 0.97 μM and is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50 = 9 μM) at -120 mV.?In thallium (Tl+) flux assays, VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2;?is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1;?and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2.
In vivoVU0134992 displayed a large free unbound fraction (fu) in rat plasma (fu = 0.213).?Consistent with the known role of Kir4.1 in renal function, oral dosing of VU0134992 led to a dose-dependent diuresis, natriuresis, and kaliuresis in rats.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/ml (145.85 mM)
Keywordswhole-cell | VU-0134992 | VU0134992 | selective | Potassium Channel | patch-clamp | oral | natriuresis | Kir4.1 | KcsA | kaliuresis | Inhibitor | inhibit | hypertension | electrophysiology | diuresis
Inhibitors RelatedMinoxidil sulfate | Quinine sulfate dihydrate | Hydrochlorothiazide | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Ursodeoxycholic acid | Cloperastine hydrochloride | Minoxidil | Indapamide
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$34.00/2mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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