Vildagliptin
Price | Get Latest Price | ||
Package | 1Kg/Bag | 25Kg/Bag | 100Kg/Bag |
Min. Order: | 1Kg/Bag |
Supply Ability: | 20 tons |
Update Time: | 2025-01-03 |
Product Details
Product Name: Vildagliptin | CAS No.: 274901-16-5 |
EC-No.: 630-410-0 | Min. Order: 1Kg/Bag |
Purity: 99% up, High Density | Supply Ability: 20 tons |
Release date: 2025/01/03 |
Product Information
Product name | Vildagliptin |
CAS No. | 274901-16-5 |
Molecular Formula | C17H25N3O2 |
Molecular Weight | 303.404 |
Quality Standard | 99% up by HPLC |
Appearance | White or whitish solid powder |
COA of Vildagliptin
ITEMS | SPECIFICATION | RESULT |
Appearance | White or whitish solid powder | White solid powder |
Identity | High-performance liquid chromatograph HPLC: The retention time of test sample major peak complies to reference standard | Almost the same |
IR Infrared spectrometry: The IR spectrum of test sample should comply to reference standard | Almost the same | |
Melting point | 148.0 。C - 152.0。C | 148.6.0。C-149.1。C |
Loss on drying | ≤ 1.0% | 0.36% |
Residual on ignition | ≤ 0.1% | 0.04% |
Related substance | Any single impurity ≤ 0.1% Total impurities ≤ 1.0% | Conforms 0.65% |
Heavy metals | ≤ 20 ppm | < 10 ppm |
Assay | 99.0% - 102.0% | 99.19% |
Conclusion | The sample complies with the above specification |
Usage
Vildagliptin is a selective, competitive and reversible DPP24 inhibitor. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like polypeptide 1 (GLP-1) are important hormones to maintain glucose concentration in the body, and both have incretin effects. The insulin-stimulating effect of GIP in patients with type 2 diabetes is impaired, and only GLP-1 can play the role of insulin-stimulating hormone secretion. GLP-1 also inhibits glucagon secretion and suppresses gastric emptying to increase satiety (suppression of appetite). DPP24 binds to proteins and exists in many tissues, such as kidney, liver, brush border of small intestinal membrane, pancreatic duct, lymphocytes, endothelial cells, and it can rapidly degrade GLP-1 by hydrolyzing the N-terminal 2 alanine of GLP-1. inactivated. This product inhibits the activity of this enzyme by combining with DPP24 to form a DPP24 complex. It increases the concentration of GLP-1 and promotes the production of insulin by islet β cells, while reducing the concentration of glucagon, thereby reducing blood sugar. and had no significant effect on body weight.
Vildagliptin can reduce fasting and postprandial blood glucose levels, postprandial glucagon secretion and improve B cell function, providing a new option for the treatment of type 2 diabetes patients. Safety and effectiveness of this medicine in combination with other medicines.
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$1.00/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2025-01-03 | |
$0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-12-12 | |
$39.00/10mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$0.00/10g |
VIP3Y
|
HangZhou RunYan Pharma Technology Co.,LTD.
|
2024-09-10 | |
$19.10/1KG |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-09 | |
$0.10/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-07-12 | |
$0.00/25kg |
VIP1Y
|
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
|
2024-05-15 | |
$34.00/1kg |
VIP2Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-25 | |
$0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-12 | |
$23.00/1kg |
Wuhan Boyuan Import & Export Co., LTD
|
2024-04-11 |
- Since: 1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.