Product Details
| Product Name:
VB124 |
CAS No.:
2230186-18-0 |
| Purity:
99.21% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | VB124 |
| Description | VB124 is an orally active, potent and selective MCT4 inhibitor. VB124 blocked lactate import (IC50 value of 8.6 nM) and export (IC50 value of 19 nM) in MDA-MB-231 cells. VB124 is selective for MCT4 over MCT1 and shows minimal MCT1 inhibitory activity in MCT1-expressing BT20 cells (IC50 value of 24 μM). |
| In vitro | VB124 blocks lactate import (IC50 of 8.6 nM) and export (IC50 of 19 nM) in MDA-MB-231 cells engineered to express MCT4 as the sole major plasma membrane lactate transporter; VB124 is selective for MCT4 over MCT1 and shows minimal MCT1 inhibitory activity in MCT1-expressing BT20 cells (IC50 of 24 μM). [1] |
| In vivo | METHODS: Mice were treated with a supramaximal dose of VB124 (30 mg/kg twice daily for 180 days) and the effects on body, heart, liver, or lung weights were observed.
RESULTS VB124 had no effect on body, heart, liver, or lung weights.
METHODS: Osmotic minipumps were surgically implanted to continuously deliver ISO to induce hypertrophy in mice, and these mice were simultaneously treated with VB124 (30 mg/kg) by daily oral gavage for 4 weeks. We performed echocardiography on these mice at the end of 4 weeks and collected their hearts after sacrifice.
RESULTS VB124 treatment ameliorated mitochondrial structural aberrations, and MCT4 inhibition reversed many of the pathological features of ISO-induced cardiac hypertrophy, including metabolic perturbations and mitochondrial structural damage. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 90 mg/mL (210.8 mM), Sonication is recommended.
|
| Keywords | VB124 | VB-124 | VB 124 |
| Inhibitors Related | 7ACC1 | BAY-8002 | AZD0095 | MCT1-IN-3 | Niflumic acid | D-Phenylalanine | AZD3965 | MSC-4381 | α-Cyano-4-hydroxycinnamic acid | 7ACC2 | AR-C155858 | Lactate transportor 1 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1mg |
VIP1Y
|
Hubei Chuchang Biotech Co., Ltd.
|
2024-03-29 |
United States