Ursodeoxycholic Acid NEW
Price | Get Latest Price | ||
Package | 1Kg/Bag | 25Kg/Bag | 100Kg/Bag |
Min. Order: | 1Kg/Bag |
Supply Ability: | 20 tons |
Update Time: | 2024-12-26 |
Product Details
Product Name: Ursodeoxycholic Acid | CAS No.: 128-13-2 |
EC-No.: 204-879-3 | Min. Order: 1Kg/Bag |
Purity: 0.99 | Supply Ability: 20 tons |
Release date: 2024/12/26 |
Product Information
Product name | Ursodeoxycholic acid / UDCA |
Synonyms | (4R)-4-[(3R,5S,7S,8R,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha.,5-.beta., 7-.beta.)-;Cholan-24-oic acid,3,7-dihydroxy-,(3R,5a,- 7a)-;UDCA;5.beta.-Chol-24-oic acid-3.alpha., 7.beta.-diol;Arsacol;Ursochol;Antigall;Urso (TN);Ursodiol;Antigall (TN);Actigall;Urso;Litursol;Deursil;Desocol;Ursodeoxycholic acid (JP14);Delursan;Ursodiol (USP);deoxy-;Urso Deoxy Cholic Acid;7beta-Hydroxylithocholic acid;Ursodeoxycholoc acid; |
CAS No. | 128-13-2 |
Molecular Formula | C24H40O4 |
Molecular Weight | 392.579 |
Molecular Structure | |
Quality Standard | 99% up by HPLC |
Appearance | White to light yellow powder |
COA of Ursodeoxycholic acid / UDCA
Item | Specification | Results |
Appearance | A white to light yellow powder | Conforms |
Solubility | Insoluble in water, insoluble in methylene chloride, freely soluble in ethanol, soluble in ethanol, slightly soluble in acetone. | Conforms |
Identification | IR | Conforms |
Melting point | 200-204 。C | 202-204 。C |
Loss on drying | ≤ 1.0% | 0.75% |
Specific optical rotation | +598.0 。- +62.0 。 | +59.5 。 |
Sulphated Ash | ≤ 0.10% | 0.06% |
Heavy metals | ≤ 20 ppm | 12 ppm |
Burned residue | ≤ 0.10% | 0.07% |
Chloride | ≤ 0.10% | 0.06% |
Related substances (by HPLC) | ||
Chenodeoxycholic acid | ≤ 1.00% | 0.15% |
Lithocholic acid | ≤ 0.10% | 0.01% |
Single impurity | ≤ 0.10% | 0.05% |
Total impurities | ≤ 0.15% | 0.45% |
Residual solvent | ||
Isopropanol | ≤ 0.50% | None |
Methanol | ≤ 0.30% | 0.14% |
Acetone | ≤ 0.50% | 0.12% |
Ethyl acetate | ≤ 0.50% | 0.06% |
Assay | 99% - 102% | 99.52% |
Conclusion | The sample conforms to standard |
Usage
Function and efficacy of Ursodeoxycholic acid / UDCA:
1. Increase the secretion of bile acids, leading to changes in the composition of bile acids, increasing their content in bile, and having a choleretic effect. The average bile acid secretion increased from 1.8 mmol per hour to 2.24 mmol per hour, and long-term use can increase the content of UDCA in bile without increasing the content of bile acid.
2. It can inhibit the synthesis of cholesterol in the liver, significantly reduce the amount of cholesterol and cholesterol esters in bile and the saturation index of cholesterol, which is conducive to the gradual dissolution of cholesterol in stones. In addition, UDCA promotes the formation of liquid cholesterol crystal complexes that accelerate excretion and clearance of cholesterol from the gallbladder to the gut.
3. Relax Audi (Oddi) sphincter, choleretic effect.
4. Reduce liver fat, increase the activity of catalase in the liver, promote the accumulation of liver glycogen, and improve the anti-toxin and detoxification ability of the liver.
5. Can reduce the concentration of triacylglycerol in liver and serum.
6. Inhibit the secretion of digestive enzymes and digestive juices.
7. Foreign studies have also shown that ursodeoxycholic acid has an immunomodulatory effect in chronic liver diseases, and can significantly reduce the expression of HLAI antigens in liver cells and reduce the number of activated T cells. Ursodeoxycholic acid is better than chenodeoxycholic acid (CDCA) in dissolving cholesterol stones in the body
Company Information
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- Since: 1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.