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Postion:Product Catalog >API>Digestive system drugs>Cholagogue Drugs>Ursodeoxycholic Acid
Ursodeoxycholic Acid
  • Ursodeoxycholic Acid
  • Ursodeoxycholic Acid
  • Ursodeoxycholic Acid
  • Ursodeoxycholic Acid
  • Ursodeoxycholic Acid

Ursodeoxycholic Acid NEW

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-12-26

Product Details

Product Name: Ursodeoxycholic Acid CAS No.: 128-13-2
EC-No.: 204-879-3 Min. Order: 1Kg/Bag
Purity: 0.99 Supply Ability: 20 tons
Release date: 2024/12/26

Product Information 


Product name

Ursodeoxycholic acid / UDCA

Synonyms

(4R)-4-[(3R,5S,7S,8R,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha.,5-.beta., 7-.beta.)-;Cholan-24-oic acid,3,7-dihydroxy-,(3R,5a,- 7a)-;UDCA;5.beta.-Chol-24-oic acid-3.alpha., 7.beta.-diol;Arsacol;Ursochol;Antigall;Urso (TN);Ursodiol;Antigall (TN);Actigall;Urso;Litursol;Deursil;Desocol;Ursodeoxycholic acid (JP14);Delursan;Ursodiol (USP);deoxy-;Urso Deoxy Cholic Acid;7beta-Hydroxylithocholic acid;Ursodeoxycholoc acid;

CAS No.

128-13-2

Molecular Formula

C24H40O4

Molecular Weight

392.579

Molecular Structure


Quality Standard

99% up by HPLC

Appearance

White to light yellow powder

COA of Ursodeoxycholic acid / UDCA 



Item

Specification

Results

Appearance

A white to light yellow powder

Conforms

Solubility

Insoluble in water, insoluble in methylene  chloride, freely soluble in ethanol, soluble in ethanol, slightly soluble in acetone.

Conforms

Identification

IR

Conforms

Melting point

200-204 。C

202-204 。C

Loss on drying

 1.0%

0.75%

Specific optical rotation

+598.0 。- +62.0 。

+59.5 

Sulphated Ash

 0.10%

0.06%

Heavy metals

 20 ppm

12 ppm

Burned residue

 0.10%

0.07%

Chloride

 0.10%

0.06%

Related substances (by HPLC)

Chenodeoxycholic acid

 1.00%

0.15%

Lithocholic acid

 0.10%

0.01%

Single impurity

 0.10%

0.05%

Total impurities

 0.15%

0.45%

Residual solvent

Isopropanol

 0.50%

None

Methanol

 0.30%

0.14%

Acetone

 0.50%

0.12%

Ethyl acetate

 0.50%

0.06%


Assay

99% - 102%

99.52%

Conclusion

The sample conforms to standard




Usage 


Function and efficacy of Ursodeoxycholic acid / UDCA:

1. Increase the secretion of bile acids, leading to changes in the composition of bile acids, increasing their content in bile, and having a choleretic effect. The average bile acid secretion increased from 1.8 mmol per hour to 2.24 mmol per hour, and long-term use can increase the content of UDCA in bile without increasing the content of bile acid.

2. It can inhibit the synthesis of cholesterol in the liver, significantly reduce the amount of cholesterol and cholesterol esters in bile and the saturation index of cholesterol, which is conducive to the gradual dissolution of cholesterol in stones. In addition, UDCA promotes the formation of liquid cholesterol crystal complexes that accelerate excretion and clearance of cholesterol from the gallbladder to the gut.

3. Relax Audi (Oddi) sphincter, choleretic effect.

4. Reduce liver fat, increase the activity of catalase in the liver, promote the accumulation of liver glycogen, and improve the anti-toxin and detoxification ability of the liver.

5. Can reduce the concentration of triacylglycerol in liver and serum.

6. Inhibit the secretion of digestive enzymes and digestive juices.

7. Foreign studies have also shown that ursodeoxycholic acid has an immunomodulatory effect in chronic liver diseases, and can significantly reduce the expression of HLAI antigens in liver cells and reduce the number of activated T cells. Ursodeoxycholic acid is better than chenodeoxycholic acid (CDCA) in dissolving cholesterol stones in the body


Company Information 

Article illustration



Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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