Urolithin A NEW
| Price | $42 | $66 | $132 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Urolithin A | CAS No.: 1143-70-0 |
| Purity: 99.66% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Urolithin A |
| 描述 | Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities. |
| 體外活性 | METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 μM) for 24 h. Cell viability was measured by MTT assay. RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1] METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 μM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2] |
| 體內(nèi)活性 | METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models. RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (219.11 mM) |
| 關(guān)鍵字 | Autophagy | Inhibitor | inhibit | Apoptosis | Urolithin A | Endogenous Metabolite | Drug Metabolite | Reactive Oxygen Species | DNA/RNA Synthesis |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 腸道微生物代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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