Product Details
Product Name:
UCB7362 |
CAS No.:
2610631-17-7 |
Purity:
97.38% |
Supply Ability:
10g |
Release date:
2024/11/16 |
Product Introduction
Bioactivity
名稱 | UCB7362 |
描述 | UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction. |
體外活性 | UCB7362 exhibits significantly higher potency against PMX than PMIX, with an IC50 of 7 nM for the former compared to 142 nM for the latter[1].
Additionally, UCB7362 demonstrates improved selectivity against Cat D and Renin, with an IC50 of 3889 nM and >10,000 nM, respectively[1]. |
體內(nèi)活性 | UCB7362, when administered orally at doses ranging from 10 to 60 mg/kg twice a day for 4 days, clears parasitemia from peripheral blood[1].
Furthermore, when given intravenously (IV) at 1 mg/kg and orally (PO) at 10 mg/kg in a single administration, UCB7362 exhibits moderate clearance in dogs and cynomolgus monkeys, and moderate to high clearance in rats[1]. |
存儲條件 | Shipping with blue ice. |
關(guān)鍵字 | UCB-7362 | UCB 7362 | UCB7362 |
相關(guān)產(chǎn)品 | Picaridin | PHYTOL | Kaempferol | Hydroxychloroquine | Metronidazole | Nitazoxanide | Doxycycline | Chloroquine phosphate | Diethyltoluamide | Artemisinin | Benzyl benzoate | DL-Methionine |
相關(guān)庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |